purine nucleoside phosphorylase — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T76096	Purine nucleoside phosphorylase
	Purine Nucleoside Phosphorylase, an essential enzyme in purine metabolism, plays a critical role in the purine salvage pathway. Its deficiency impairs T cell function. With inorganic orthophosphate as a co-substrate, thi...
T9727	2'-Fluoro-2'-Deoxyadenosine		Nucleoside Antimetabolite/Analog
	2'-Fluoro-2'-Deoxyadenosine is efficiently cleaved to the toxic 2-fluoroadenine (FAde) by Escherichia coli purine nucleoside phosphorylase (PNP). 2'-Fluoro-2'-Deoxyadenosine showed good in vivo activity against tumors ex...		Nucleoside Antimetabolite/Analog
T15337	Forodesine	BCX-1777,Immucillin-H	Others
	Forodesine is a potent human lymphocyte proliferation inhibitor. Forodesine is an orally active inhibitor of purine nucleoside phosphorylase (IC50s: 0.48 to 1.57 nM for human, mouse, rat, monkey, and dog PNP). It could i...		Others
T7782	3'-Deoxyguanosine		Others
	3'-Deoxyguanosine is a ligand that can be complexed with enzymes, such as purine nucleoside phosphorylase, and receptors.		Others
T1709	2'-Deoxyinosine	Guanine deoxyriboside,Deoxyinosine	Others , Endogenous Metabolite
	2'-Deoxyinosine (Guanine deoxyriboside) inhibits the growth of human colon-carcinoma cell lines and is associated with purine nucleoside phosphorylase (PNP) deficiency.		Others , Endogenous Metabolite
T67822L	Ulodesine	BCX4208	Endogenous Metabolite
	Ulodesine (BCX4208) is a purine nucleoside phosphorylase (PNP) inhibitor that inhibits PNP with an IC50 value of 2.293 nM/L. Ulodesine may be used to study hyperuricaemia.		Endogenous Metabolite
T13539	Allopurinol riboside		Others , Endogenous Metabolite , Parasite , Drug Metabolite
	Allopurinol riboside is a metabolite of allopurinol with potency against parasites. Allopurinol riboside competitively inhibits the action of purine nucleoside phosphorylase on inosine with a Ki of 277 μM.		Others , Endogenous Metabolite , Parasite , Drug Metabolite
T12399	Peldesine	BCX 34	Nucleoside Antimetabolite/Analog , HIV Protease
	Peldesine (BCX 34) is an effective, competitive, reversible, and orally active inhibitor of purine nucleoside phosphorylase. Peldesine inhibits T-cell proliferation with an IC50 of 800 nM. Peldesine can be used in resear...		Nucleoside Antimetabolite/Analog , HIV Protease
T70768	MDL-74428
	MDL-74428 is an inhibitor of purine nucleoside phosphorylase.
TNU1023	7-Deaza-2’-deoxyadenosine
	Nucleoside Derivatives –7-Deaza-purine nucleosides; Drugs and Inhibitors; Purine nucleoside phosphorylase inhibitor
T14964	CI 972 anhydrous	CI 972 (anhydrous)	Others
	CI 972 anhydrous is an inhibitor of purine nucleoside phosphorylase (PNP) (Ki: 0.83 μM) used as a T cell-selective immunosuppressive agent.		Others
T70939	8-Aminoinosine
	8-Aminoinosine is an endogenous 8-aminopurine that induces diuresis, natriuresis, and glucosuria by inhibiting purine nucleoside phosphorylase (PNPase).
T19148	5-Aza-7-deazaguanine		Others
	5-Aza-7-deazaguanine is a substrate for E. coli purine nucleoside phosphorylase (wild-type/Ser90Ala mutant) in the synthesis of base-modified nucleosides.		Others
T78379	9-Deazaguanine		Others
	9-Deazaguanine is a nucleoside analog that exhibits potent inhibitory activity against purine nucleoside phosphorylase (PNP) [1].		Others
T11313	Forodesine hydrochloride	BCX-1777 hydrochloride,Immucillin-H hydrochloride	Others
	Forodesine hydrochloride (BCX-1777 hydrochloride), a potent inhibitor of human lymphocyte proliferation, effectively induces apoptosis in leukemic cells by elevating dGTP levels. This compound is an orally active, highly...		Others
T60799	Peldesine dihydrochloride
	Peldesine (BCX 34) dihydrochloride is a potent, competitive, reversible, and orally active inhibitor of purine nucleoside phosphorylase (PNP), exhibiting IC50 values of 36 nM, 5 nM, and 32 nM against human, rat, and mous...